Synthesis and antifungal activity of carabrone derivatives.
نویسندگان
چکیده
Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity.
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ورودعنوان ژورنال:
- Molecules
دوره 15 9 شماره
صفحات -
تاریخ انتشار 2010